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An MCU (microcontroller) integrates CPU, memory, and peripherals on one chip — the core of embedded control. Selection depends on core, flash, RAM, and communication interfaces.
Required peripherals and pin count, plus flash/RAM capacity. If these fall short, the design is impossible regardless of performance.
Pin compatibility (package/pinmap), peripheral equivalence, flash/RAM, operating voltage, and firmware porting cost. A pin-compatible part within the same family is safest.
M0+ suits low-power/low-cost designs; M4 adds DSP instructions and an FPU, favoring signal processing and control computation.